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Archer™ FUSIONPlex™ Myeloid panel

Discover myeloid insights with a targeted RNA panel

Identify known and novel fusions, splice variants, expression levels, single nucleotide variants, insertions, and deletions with targeted NGS of 84 genes relevant for acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndromes (MDS) research.

Detect more with Archer FUSIONPlex NGS Panels for RNA. 

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Product details

Panel specifications

Specifications
Targeted genes84
Genomic alterationsFusions, splicing, exon-skipping, SNVs, indels, expression levels
Input nucleic acid required*≥10 ng
Recommended number of reads1.5 M
Hands-on time<3.5 hours
Total library prep time1.5 days
Platform compatibilityIllumina® and Ion Torrent™
Reagent formatLyophilized or liquid†
Supported sample typesBlood, bone marrow, fresh frozen, FFPE, BMMC, PBMC

*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.

†Liquid reagents available for Illumina platform only.

Gene targets

ABL1
AKT3
ASXL1
BCR
BRAF
CALR
CBFB
CBL
CD274
CEBPA
CHD1
CHIC2
CREBBP
CSF1R
CSF3R
CTLA4
DCK
DNM2
DNMT3A
ERG
ETV6
EZH2
FBXW7
FGFR1
FGFR2
FGFR3
FLT3
GATA1
GATA2
GLIS2
GNAS
ID4
IDH1
IDH2
IKZF1
IKZF3
IRF4
IRF8
JAK1
JAK2
JAK3
KAT6A
KDM6A
KIT
KMT2A
KRAS
MECOM
MKL1
MLLT10
MLLT4
MPL
MUC1
MYC
MYD88
MYH11
NF1
NOTCH1
NPM1
NRAS
NUP214
NUP98
PDCD1
PDCD1LG2
PDGFRA
PDGFRB
PHF6
PICALM
PML
PTPN11
RARA
RBM15
ROS1
RUNX1
RUNX1T1
SETBP1
SETD2
SF3B1
SLC29A1
SRSF2
TCF3
TFG
U2AF1
WT1
XPO1

Interested in customizing panel content?

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Benefits

  • Detect more—Comprehensive fusion detection is enabled by open-ended targeted amplification, delivering detection of both novel and known fusions, while Archer Analysis’s multifeatured pipeline provides data confidence and clear visualization of breakpoints.
  • Less QNSAnchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide range of sample types, including low-input and degraded samples such as FFPE tissue.
  • Achieve efficiency—Streamlined workflows for your lab are enabled by choice of reaction-sized lyophilized reagents or high-throughput liquid reagents, while parallel workflows across all Archer panels provide efficient genomic characterization.
  • Customize content—Use Assay Marketplace to modify any panel to fit your lab’s needs or start from scratch to keep up with the pace of discovery.

Ready to start?

Talk with our technical sales team. Learn how the FUSIONPlex Myeloid panel can identify key genomic alterations for your research.

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Frequently asked questions

Related products

References

RUO23-2278_001